feat(iit): Complete CRA Agent V3.0 P0 milestone - autonomous QC pipeline

P0-1: Variable list sync from REDCap metadata
P0-2: QC rule configuration with JSON Logic + AI suggestion
P0-3: Scheduled QC + report generation + eQuery closed loop
P0-4: Unified dashboard + AI stream timeline + critical events

Backend:
- Add IitEquery, IitCriticalEvent Prisma models + migration
- Add cronEnabled/cronExpression to IitProject
- Implement eQuery service/controller/routes (CRUD + respond/review/close)
- Implement DailyQcOrchestrator (report -> eQuery -> critical events -> notify)
- Add AI rule suggestion service
- Register daily QC cron worker and eQuery auto-review worker
- Extend QC cockpit with timeline, trend, critical events APIs
- Fix timeline issues field compat (object vs array format)

Frontend:
- Create IIT business module with 6 pages (Dashboard, AI Stream, eQuery,
  Reports, Variable List + project config pages)
- Migrate IIT config from admin panel to business module
- Implement health score, risk heatmap, trend chart, critical event alerts
- Register IIT module in App router and top navigation

Testing:
- Add E2E API test script covering 7 modules (46 assertions, all passing)

Tested: E2E API tests 46/46 passed, backend and frontend verified
Made-with: Cursor

backend/prisma/migrations/20260226_add_equery_critical_events_cron/migration.sql

@@ -0,0 +1,67 @@
+-- P0-3: eQuery 闭环 + 重大事件归档 + 项目 cron 配置
+
+-- 1. eQuery 表（AI 自动生成的电子质疑，具有完整生命周期）
+CREATE TABLE IF NOT EXISTS iit_schema.equery (
+  id              UUID PRIMARY KEY DEFAULT gen_random_uuid(),
+  project_id      TEXT NOT NULL,
+  record_id       TEXT NOT NULL,
+  event_id        TEXT,
+  form_name       TEXT,
+  field_name      TEXT,
+  qc_log_id       TEXT,
+  report_id       TEXT,
+  query_text      TEXT NOT NULL,
+  expected_action TEXT,
+  severity        TEXT NOT NULL DEFAULT 'warning',
+  category        TEXT,
+  status          TEXT NOT NULL DEFAULT 'pending',
+  assigned_to     TEXT,
+  responded_at    TIMESTAMPTZ,
+  response_text   TEXT,
+  response_data   JSONB,
+  review_result   TEXT,
+  review_note     TEXT,
+  reviewed_at     TIMESTAMPTZ,
+  closed_at       TIMESTAMPTZ,
+  closed_by       TEXT,
+  resolution      TEXT,
+  created_at      TIMESTAMPTZ NOT NULL DEFAULT now(),
+  updated_at      TIMESTAMPTZ NOT NULL DEFAULT now()
+);
+
+CREATE INDEX IF NOT EXISTS idx_iit_equery_project ON iit_schema.equery(project_id);
+CREATE INDEX IF NOT EXISTS idx_iit_equery_project_status ON iit_schema.equery(project_id, status);
+CREATE INDEX IF NOT EXISTS idx_iit_equery_record ON iit_schema.equery(record_id);
+CREATE INDEX IF NOT EXISTS idx_iit_equery_assigned ON iit_schema.equery(assigned_to);
+
+-- 2. 重大事件归档表（SAE、重大方案偏离等长期临床资产）
+CREATE TABLE IF NOT EXISTS iit_schema.critical_events (
+  id              UUID PRIMARY KEY DEFAULT gen_random_uuid(),
+  project_id      TEXT NOT NULL,
+  record_id       TEXT NOT NULL,
+  event_type      TEXT NOT NULL,
+  severity        TEXT NOT NULL DEFAULT 'critical',
+  title           TEXT NOT NULL,
+  description     TEXT NOT NULL,
+  detected_at     TIMESTAMPTZ NOT NULL,
+  detected_by     TEXT NOT NULL DEFAULT 'ai',
+  source_qc_log_id  TEXT,
+  source_equery_id  TEXT,
+  source_data     JSONB,
+  status          TEXT NOT NULL DEFAULT 'open',
+  handled_by      TEXT,
+  handled_at      TIMESTAMPTZ,
+  handling_note   TEXT,
+  reported_to_ec  BOOLEAN NOT NULL DEFAULT false,
+  reported_at     TIMESTAMPTZ,
+  created_at      TIMESTAMPTZ NOT NULL DEFAULT now(),
+  updated_at      TIMESTAMPTZ NOT NULL DEFAULT now()
+);
+
+CREATE INDEX IF NOT EXISTS idx_iit_critical_event_project ON iit_schema.critical_events(project_id);
+CREATE INDEX IF NOT EXISTS idx_iit_critical_event_type ON iit_schema.critical_events(project_id, event_type);
+CREATE INDEX IF NOT EXISTS idx_iit_critical_event_status ON iit_schema.critical_events(project_id, status);
+
+-- 3. 项目表新增 cron 配置字段
+ALTER TABLE iit_schema.projects ADD COLUMN IF NOT EXISTS cron_enabled BOOLEAN NOT NULL DEFAULT false;
+ALTER TABLE iit_schema.projects ADD COLUMN IF NOT EXISTS cron_expression TEXT;